Development of PET Probes
PET (positron emission tomography) is a computational imaging technique by detecting a positron-emitting radionuclide, which produces a three-dimensional image or picture of functional processes in the body.
Development of PET probes is the technology synthesizing labeled drugs suitable for PET detection. The probe enables to image dynamics of the drug in the body, which is useful for the development of new drugs.

Rho kinase
Rho kinase (also known as ROCK) has been identified as a serine/threonine protein kinase, playing important role in intracellular signaling pathway.

Platelet aggregation inhibitory activity
Platelet aggregation inhibitory activity is an activity of the compound to inhibit platelet aggregation, the main function of platelets.

Anti-intimal hyperplasic activity
Intimal hyperplasia is a symptom of thickening of intimal layer of blood vessels. The rumen of the vessels may be narrowed and it may result in thrombosis. It is suggested that intimal hyperplasia play an important role for the genaration of atherosclerosis. Anti-intimal hyperplasic activity is an activity of the compound to inhibit intimal hyperplasia.

Anti-thrombosis drugs
Anti-thrombosis drugs are the drugs for the treatment of ischemic diseases induced by thrombi (blood clots) which prevent blood flow. Ischemic diseases include myocardial infarction and cerebral infarction, and so son.

Mechanism of Action
Mechanism of action is a mechanism on how a drug exhibits effects or efficacy.
Elucidation of mechanism of action is crucial for developing new drugs, and technologies for elucidating mechanism of action gain much attention.

Screening
Screening is a flow to select clinical candidates from numerous compounds, based on efficacy and safety.

Anti-Atherosclerosis Drug
Atherosclerosis is the condition in which an artery wall thickens as the result of a build up atheromatous plaques.
The atheromatous plaques eventually lead to plaque ruptures and clots inside the artery lumen over the ruptures, causing the formation of a thrombus that will rapidly slow or stop blood flow, leading to tissue necrosis.
Anti-atherosclerosis drug is a class of drugs for the treatment for atherosclerosis.

Enzyme Inhibitor
Enzyme inhibitors are molecules that bind to enzymes and block their activity. Many drugs categorized to be enzyme inhibitors, kill a pathogen or correct a metabolic imbalance.

Identification
To determine the structure and profiles of a chemical substance isolated.

Drug Western method
(Patented in Japan, Europe)
Drug Western method is a biotech methodology which is utilized for the identification of target proteins of the drugs. This technology, invented and patented by DWTI, allows us to identify the genes for trance amounts of drug-binding proteins without purification.

Protein kinase
A protein kinase is an enzyme that modifies other proteins by chemically adding phosphate groups to them (phosphorylation) using ATP (adenosine-5’-triphosphate) as a substrate.

Molecular Pharmacology
Pharmacology is the study of drug action. Pharmacology deals with how drugs interact within biological systems to affect function. Molecular pharmacology explains drug action in the terms of genes.

Atherosclerosis obliterans
Arteriosclerosis obliterans is an occlusive arterial disease which is typically seen in medium and large arteries of the lower extremity. The lumen of the vessel may be narrowed, leading to tissue necrosis. Anti-platelet drugs are treated for mild cases and other classes of drugs are used for severe cases.

Derivatives
A derivative is a compound that is formed from a similar precursor compound, not greatly apart from it.

Anti-glaucoma Drug
Glaucoma is an optic neuropathy causing damage to the optic nerve including retina, leading to vision loss and eventual blindness.
Anti-glaucoma drugs are a member of a class of medicines that prevents the vision loss or improves the vision.

Phosphorylation
Phosphorylation, alternatively known as a phosphoryl transfer reaction, is the addition of a phosphate (PO4) group to a protein.