|Target disease||Glaucoma / Ocular hypertension|
|Development stage||Initiated phase I / IIa trial in U.S.|
|License out to||in-house developed
（contractor : Allysta Pharmaceuticals, Inc.）
|Overview||This product is a multikinase inhibitor that inhibits various kinds of protein kinases, including leucine-rich repeat kinase (LRRK),and is suggested to stimulate the drainage of aqueous humor from the main outflow tract via the trabecular meshwork and Schlemm’s canal, thus lowering intraocular pressure. The long-term persistence of this potent intraocular pressure-lowering effect has been demonstrated in animal studies.
We made a presentation of the effect of treatment for exudative age-related macular degeneration (wet AMD) jointly with Mie University at ARVO (*) held in May 2015.
In March 2018 we initiated phase I / IIa trial in U.S.
※The Association for Research in Vision and Ophthalmology
|2016||Apr.||Initiated non-clinical studies|
|2018||Jan.||Completed non-clinical studies|
|Mar.||Initiated phase I / IIa trial in U.S.|